I'm going to differ from the others on this one...the first partition will be faster then the other remaining partitions as you will be reading/writing to the fastest part of the drive.
This may not happen in the first 1/3 of the drive, the best way would be to run HDTune against the drive, and note where the drive starts dropping off.
Will this be enough for you to see in daily use...doubt it. Would I recommend it...yes. I normally load my games on the first partition of the second drive after determining how large the partition can be while keeping in the fastest part of the drive.