compression

I've been helping building PC's lately, and I often see people with too small SSD's, at least when you take their 1 or 2 most played games into account. So that got me thinking back to Sandforce if anyone remembers (10 years ago or so). Those disks natively compressed content before storing it...

My question is if you use mkvtoolnix and do not check of the option "no compression" and let it stay on the option "determine automatically"- for audio, video and subtitle (pgs) will the quality lessen / be lowered? Which means that it will not be a remux but become an encode. In makemkv there...