If your in the US, you may also want to be sure whatever you do is HIPPA compliant.
http://www.healthit.gov/providers-professionals/your-mobile-device-and-health-information-privacy-and-security
For me I went from HTPC + WMC and/or XMBC to Roku(s) + Plex for one HUGE reason. WAF (wife acceptance factor).
I hate getting calls that this or that "broke" or doesn't work (which seems to only happen when I am gone). Time Warner puts an app out on Roku so we don't need a set-top box or...
I have the Asrock X99M Extreme4 and like it. I have my 5820K at 4.2ghz using just it's auto tune settings.
I had a UD4 board but it didn't support the 4x m.2 pcie (only 2x I think) and I have a XP941 drive that is 4x.
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