No, I haven't had a problem and my setup is similar to the solution you describe where my "Users" directories are both on C and D. All my larger user directories like Downloads, Videos, etc. I moved off SSD (C drive) and onto spinning disk (D drive) using the Location tab under the folders properties. I installed WMC without a hitch, that's my gaming desktop so probably not completely like your setup since it's a laptop. Are you running multiple drives/partitions?
"I Know Bad From Good and Where to Get Free Refills" - Mr. Harding, The Schizophrenic Stock Broker
"The Problem With the World is That Everyone is a Few Drinks Behind" - Humphrey Bogart