Thanks for the feedback here, all... I ended out just booting with an Acronis CD, taking a snapshot of the drive, and doing a clean reinstall just to be on the safe side. Again, this is what I'd normally do when "upgrading" to a new OS anyway, but this time around, given all the hype around Win8's upgrade process, I figured I'd give it a shot. My intent was to go back to a "bare metal" install anyway but retain my data after having a few "glitches" after the Win7->8 in-place upgrade.
All seemed to be working ok after the upgrade, but before my last reboot, I had reinstalled VMware, installed Asus' "AiCharger" software, and also added Media Center via the "Add Features to Windows" control panel item. (I'm leaning toward the Asus as the culprit, but I'm not sure.) When I rebooted the last time, it went into a BSOD loop (for lack of a better term) where it would throw a "System Thread Exception Not Handled" error, would try to do an auto repair, and would then tell me that Windows was unable to automatically repair, leaving me at the manual repair options. Those included the "Refresh my PC" and "Reset my PC" options as well as the manual command prompt-type options. After doing a few things to manually try and fix from the command prompt as well as booting into safe mode for a few things, I just decided "screw it, I'll reimage." I tend to normally be of the same mind as lxskllr said above, which is not to trust any of the helpful "automatic" type of options, but the refresh and reset options were intriguing, though, hence my question.
If it wasn't my primary machine, I'd have been tempted to go ahead and try, but it's not worth the risk. I'm pretty sure that it won't touch secondary drives like dlock13 said above, but why chance it? Thanks again for the input, folks.